Tag: Depression

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Creature Comforts: Pets and Mental Health

Genevieve1 Comment

pets

There’s nothing better than a cozy evening spent snuggled up with your dog or cat, right? Pets come with lots of responsibilities, but also with plenty of benefits for our health. I know how it weighs out for me- strongly positive. My dog has been an enormous help in my recovery from depression, and she also helps me regulate my nervous system when Sensory Processing Disorder gets in the way. But what does science say about pets and mental health?

Animal Assisted Therapy

I’m particularly interested in how pet ownership affects mental health and wellbeing, but perhaps it’s best to start with the research on therapeutic interventions. I’m guessing that it’s much easier to study the effects of human-animal interactions in the context of short visits than in the context of pet ownership for a few reasons.

  1. It’s more difficult to determine causality in cases of pet ownership. Are people with pets healthier, or are healthier people more likely to have pets?
  2. Many pet ownership studies rely on participants’ ability to report results over a long period of time, as opposed to short AAT sessions.
  3. AAT is implemented and monitored by professionals who keep detailed records.

Before I even read any articles, I was expecting to find that AAT is backed by a sizeable amount of evidence supporting the link between pets and mental health. After all, I’d seen those news stories about unconventional Emotional Support Animals, and those aren’t necessarily trained to perform a therapeutic role.

A 2017 review compiled data from 18 studies of AAT. In 15 of those studies, at least one positive effect was found, although the authors point out that most of the studies found no significant effect on treatment outcome. Overall, the review suggests that AAT, particularly dog assisted therapy, provides mild to moderate effects. Not bad, given how many variables are unavoidable when it comes to animal interactions.

Therapy dogs have been successfully used as part of treatments for elderly Alzheimer’s patients as well as in promoting social interactions in a long-stay psychiatric population.

So, if AAT is mildly or moderately effective in short “doses”, how does near-constant interaction with animals affect us? I’m wary of extrapolating too far because pet ownership is certainly not just a scaling-up of petting a therapy dog at your university’s library during finals. There’s a lot more to it; perhaps the responsibility, stress and frustration when a pet misbehaves, and of course, the emotional pain of losing a beloved companion outweigh the benefits of interacting with animals.

My Roommate is a Quadruped

Did y’all see that Reddit thread about how weird it would sound if we called our pets “roommates”?

reddit

My roommate ate every Lactaid pill out of my mother’s purse and left all the wrappers on the floor. The other day, I walked into the kitchen to find my roommate standing on the table, eating jam right out of the jar. I know someone whose roommate ate crayons and then pooped rainbows for a week.

Pet owners share their lives with their pets; not just their time and energy, but their homes, too. Many people consider their pet as part of their family, and I can see why (and not just because I’m one of those people). Anecdotally, I can understand why pets and mental health benefits are often linked in our minds.

Social Support

A qualitative study of people with mental health conditions, conducted in 2016, had participants map out their social support networks in three concentric circles, the innermost circle being the most important. 25 of the 54 participants were pet owners, and the majority of them placed their pets in the innermost circle. The researchers identified several common ways in which participants reported benefits from owning pets.

  • Establishing routines
  • Distraction from symptoms (e.g. hallucinations, suicidal ideation)
  • Sense of certainty that pets would reliably provide support
  • Caring for pets gave participants a sense of meaning
  • Reducing the stigma of mental illness through pets’ unconditional acceptance of owners
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This meme will one day be horribly outdated, but that day is not today.

Another study with a similar design had me grinning from ear to ear- some of the transcripts of participants talking about their pets are delightful. Although this study focused more on chronic physical illnesses, I noticed some relevant parallels. The authors describe the apparent infantilization of pets and hypothesize that it provides a sense of reciprocity that chronic illness sufferers may not have in their human relationships. Those with chronic illness- physical or mental- often report feeling like a burden on others. Doting on a pet, it seems, alleviates some of those feelings and makes the pet owner feel needed.

Soothing or Stressful?

Everyone feels distressed from time to time. Petting an animal can help calm someone in distress by reducing blood pressure and reactions to mental stress. One study, hilariously called “Friends with Benefits: On the Positive Consequences of Pet Ownership,” experimentally found that pets were able to keep their owners from dwelling on negativity caused by social rejection.

For people with Sensory Processing Disorder, pets can provide a myriad of soothing sensory benefits. They offer tactile feedback in the form of fur, feathers, wool, etc., and the extra snuggly ones can provide deep pressure (depending on how heavy they are). Indirectly, pets provide proprioceptive and vestibular input simply by requiring interaction- walking, feeding, bathing, and training them. Pets tend to have less complex, more predictable social cues, which may make them less stressful to interact with than humans, especially for people who are easily overwhelmed.

Some of the Drawbacks

On the other hand, pets are their own entities with their own agendas. They don’t always do what we want them to. For instance, my dog barking at me while I try to drink my coffee in the morning is definitely NOT soothing. There are distinct disadvantages to owning a pet when you’re affected by SPD and/or mental illness. They can be messy and loud (unless you like those things- then add that to the advantages list), and sometimes they get in your personal space when you don’t want to be touched.

The Intersection of Pets and Mental Health for Me

Despite the frustrations and occasional discomfort, I’ve found pet ownership to be immensely helpful and rewarding. My dog reminds me to get outside and walk, to look up from my computer every once in a while (she’s being quiet…too quiet), and to enjoy all the little pleasures- long naps, eating with gusto, and rolling in smelly things.

Wait- not that last one. Don’t do that.

February’s Grip

GenevieveLeave a comment

The sun has left us for a few rotations, only peeking out from behind the clouds in short intervals. It smiles down on us weakly, filtered through miles of gauzy cotton. How did I manage a more northern latitude? Just a day or two of relative darkness is enough to upset my balance.
Maybe I’m searching for explanations that don’t exist. To excuse my mood as simply a mirror for what’s outside. It seems impossible that such a minute change could affect me so drastically, and yet when I embark on my morning walk, the slow, chemical drip of melatonin invariably calls me back to bed. So, I hunker down, and I wait for February’s grip to loosen.
Love,
Your Brain

Some Thoughts on Running

GenevieveLeave a comment

CW: mentions of self-harm

Sometimes I run because it’s when I feel strongest. I run because I love the feeling of my muscles working beneath my skin, my breath matched to my stride. Breathe in for three steps, breathe out for three steps. I love the sense of accomplishment, knowing that my body can carry me further than I think it can. Sometimes I run because it gives me joy. The simple pleasure of the wind in my hair and the sun on my face, moving with a body I’m thankful for. My body is a canvas for my mental state; when I’m well, I run for the joy of it. When I’m unwell, I run because it’s just another way to hurt myself. I run because at mile three I’m still thinking about cutting, but by mile five my brain is numb. Breathe in for three steps. Breathe out for three steps. I run because maybe if I can push my body to obey me, my brain might follow suit. I run because to be exhausted is to be empty, and where could my depression have gone except to have been left behind on the path? Expelled by my lungs, my racing heart, my wrung-out muscles. I run because it makes me feel good, and because sometimes, it makes me feel nothing at all.

Love, 

Your Brain

Why I Sometimes Call Self-Care “Corporeal Maintenance”

Genevieve2 Comments

Sometimes I wish someone would just roll me into the literal body shop and get me a self-care tune-up. Alas, it doesn’t work that way.

I’ve stopped using the term “self-care” to describe a lot of the things I do for myself. Hear me out, though. It’s not because there’s anything wrong with calling it self-care; it’s just that a lot of self-care tasks are not as flowery and gentle as the term implies. Sometimes you have to buckle up and make that phone call you’ve been avoiding so that your dentist doesn’t think you dropped off the face of the planet. (And so that you can get your teeth cleaned, I guess.)

I’ve found that reframing some self-care tasks as “corporeal maintenance” helps me tackle them with less procrastination. Something about approaching these tasks as simply maintenance and upkeep feels less daunting.
Here are some examples:

“Oh, my ‘check hydration tank’ light is on. Better go drink some water.”
Or
“Didn’t I just go grocery shopping, like…oh, yeah, I guess it’s been a while. I should probably get some fuel for this week.”

If I call it “self-care,” I’m likely to not do it – either because I don’t care, or because I don’t feel worthy of being cared for. But, if you want to keep driving to the things you do care about, you have to get the oil changed every once in a while.

There’s a lot of talk about self-care these days; some criticize it and some embrace it whole-heartedly. There tends to be an atmosphere of self-indulgence when we discuss it; as if every act of caring for ourselves is rooted in all-encompassing positivity. And yes, self-care can be self-indulgent and rooted in self-love. Those things are necessary. But self-care is also doing the things that aren’t very fun but are kind of non-negotiable when it comes to being healthy.

It may very well be the case that you do complete these tasks out of self-love, and I think that’s great. In fact, that seems like a wonderful goal to work towards. But if you’re not there yet, and calling those unpleasant/boring tasks “self-care” feels insincere, go ahead and call them something else. Whatever floats your goat.

Love, 

Your Brain

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What I’ve Learned About Self-Harm

GenevieveLeave a comment

“I need a new bathing suit”, I told my mother before heading out the door. A list of criteria floated through my mind. It needed to have shorts, or maybe a skirt, which had to go down to my mid-thigh. Of course, it should be cute so as not to arouse suspicion or too many questions.

Buying a bathing suit with a skirt was just one of many ways I hid my self-harm from those around me. In my third year of college I became depressed, and the following summer I started self-harming. I did it in secret and hid the evidence. I knew that altering my clothing choices would spark concern, so I continued to wear shorts that barely covered the still-healing wounds. Looking at photos from this time is painful. I remember desperately trying to appear well; smiling while anxiously pulling my shorts down to cover my secret. It consumed me entirely until cutting was all I thought about. Fighting the urge to do it was like trying not to sneeze. I would think about it constantly for days or weeks until I could take no more, and give in just to make the thoughts stop.

At age 4, I was diagnosed with Sensory Processing Disorder, a neurological condition that affects the brain’s ability to make sense of a world filled with sensory stimuli. I screamed getting my hair washed, I refused to go outside until my mittens were tucked into my sleeves, and anytime I fell down, I held my breath until I passed out. As a child, the world was a scary place, and although I learned to cope with my differences, the pressure of college and my looming adult life plunged me into numbness and depression. I began to feel outside of myself when in busy areas, and when I closed my eyes, I felt a gentle rocking as if I were on a boat. Cutting was a way for me to ground myself when things felt out of control.

All of this has taken me months to discover, though, and it was terrifying to not understand my own actions. Reaching out to my loved ones helped immensely. After months of hiding my self-harm from my mother, I told her about it the night before I moved back to school. When I showed her, she looked at the rows of raised, red scars and softly said: “that’s what I thought was happening.” All of the effort I had put into protecting her from the truth, for nothing. She had known for weeks, and I probably caused her more worry by staying silent. The next day, I left to begin my final year of college, four states away. I began seeing a therapist who encouraged me to create art that expressed my emotions, and when I found myself in a hazy stupor, I would open my sketchbook instead of turning to self-harm. But removing self-harm from my list of coping mechanisms made me feel wildly out of control, and I spiraled into a state of suicidal ideation. By the time I reached one month without engaging in self-harm, my therapist was gently suggesting hospitalization. Thankfully, I switched medications, and although it wasn’t the right one for me, it helped enough to keep me safe.

What I’ve learned about self-harm and other damaging coping behaviors is that they give you the illusion of control. Over time, however, it grows into a slippery beast of its own. You may eventually wonder how this action that you perceived as giving you control has come to hold you so tightly, until it doesn’t feel like a choice at all. Months of therapy, various medications, and the unwavering support of my friends and family have slowly allowed me to come out of the darkness. Today, I have gone over 10 months without self-harm, and I’ve come to understand that saying “no” to that self-harm voice gives me true control that is much more effective than self-harm ever was.

A black and white image of a set of human female chromosomes scattered against a black background

Understanding MTHFR and Depression

Genevieve6 Comments

This article was published in February 2019 and updated in November 2021.

Table of Contents

  1. L-methylfolate: My Silver Bullet?
    1. Why the Reluctance?
  2. The Science
    1. First, Some Background
    2. Two Mutations
    3. Enzyme Activity
    4. MTHFR and Mental Illness
  3. The Future of Mental Health Treatment

A couple of years ago, my psych nurse suggested we send some of my cheek cells to a lab for genetic testing. I was severely depressed and hadn’t had much success with the antidepressants I’d tried. With a significant family history of depression and other mental health issues, it seemed likely that there was a genetic component for me.

By National Human Genome Research Institute – Public Domain, https://commons.wikimedia.org/w/index.php?curid=41175399

L-methylfolate: my silver bullet?

My psych nurse told me that for some people, a genetic abnormality affects the activity of a particular enzyme that’s implicated in psychiatric conditions (and many other illnesses). People with this mutation can be helped by taking what’s essentially a supplement (I believe she even said it was “like a vitamin”), l-methylfolate. By taking the product of this hindered metabolic process in pill form, it fills in the gaps that your faulty enzymes have left behind. Because it was a rather serious situation, we decided that we may as well add this supplement to see if it helped. I told her I’d think about the genetic testing.

A couple of weeks later, we revisited the idea. The l-methylfolate seemed to be helping a little, but not dramatically. I had figured that the testing would be unnecessary; if the l-methylfolate helped, we’d know I was a mutant. If it didn’t, we’d move on to something else. It wasn’t that cut and dry.

Why the reluctance, you ask?

Perhaps there was a little anxiety about what I might find out about myself, but I suppose that’s a topic for my therapist. Mostly, I was skeptical. Genetic research has advanced tremendously, but the mechanistic aspects of mental illnesses are still rather poorly understood. Could a DNA profile really tell me why I was depressed?

Well, I’ll spoil the ending for you and say “Yes. Kind of.” Curiosity won out, and I agreed to part with some of my genetic material in the name of science and not wanting to be depressed forever. The results, pared down to what’s important for clinicians and patients to understand, were interesting- and rather ambiguous.

The science behind MTHFR mutations

The gene in question is called methylenetetrahydrofolate reductase (MTHFR). Our genes code for proteins, and enzymes like MTHFR are one type of protein. MTHFR is involved in something called one-carbon metabolism, which has effects on the production of neurotransmitters.

First, some genetics background

Harken back to your high school or college biology class; remember alleles?  A gene and an allele are not exactly the same thing. A gene is essentially a small segment of a chromosome. The DNA sequence of a gene codes for a specific sequence of amino acids, which comprise proteins. An allele, however, is a variation of a gene. For each gene, you got one allele from your mom and one from your dad. I received a combination of normal and mutated MTHFR genes. Mutation is how variation occurs, and the process itself is neither good nor bad; it just is. Some mutations are adaptive, some are neutral, and some are deleterious.

Two MTHFR mutations

There are two main mutations on the same allele that seem to affect this enzyme’s activity. As usual, the names are cryptic; they’re called C677T and A1298C. The numbers and letters refer to where in the allele one nucleotide (or one “digit” in the DNA code) has been changed to another, and the substitution that’s taken place. In general genetics contexts, heterozygotes have different alleles from mom and dad, while homozygotes have identical alleles.

By Darryl Leja, National Human Genome Research Institute – https://www.genome.gov/dmd/img.cfm?node=Photos/Graphics&id=85182, Public Domain, https://commons.wikimedia.org/w/index.php?curid=50712171

In the context of mutation research, there is typically one genotype that is referred to as “wild type,” meaning it contains no mutations and has full function. In this case, imagine the big “B” homozygous chromosome in the image above as the “wild type” and the little “b” as the mutation in question. The letters in examples like this are simply ways to represent alleles in a theoretical framework. The order of the letters is written out because, without further research, it’s difficult to tell which parent the mutation came from.

To bring it around to MTHFR, I’m a heterozygote for both of the main mutations (this is called “compound heterozygosity”). My genotype for C677T is C/T. The C (cytosine) is the nucleotide in the normal allele and the T (thymine) is the substituted nucleotide in my mutated version. I got the C from one parent and the T from the other. I’m also a heterozygote when it comes to the A1298C mutation. My genotype is A/C, where the A (adenosine) is the normal one and the C is the mutant.

The problem lies in the metabolism of a key metabolic precursor: a biologically-active form of folate. The product of this reaction is 5-tetrahydrofolate, which provides a methyl group for epigenetic regulation. In other words, when MTHFR is mutated, the system that controls gene expression and, ultimately, neurotransmitter production, is affected by a lack of this enzyme’s product because the enzyme’s function is reduced. This is the gap that the supplement I take fills in.

Enzyme activity

Meta-analyses suggest that C677T homozygous mutants (they have two mutated copies) have a 75% reduction in MTHFR activity, and A1298C homozygous mutants have a 39% reduction in enzyme activity. Heterozygotes for each mutation have less severe reductions in activity, but if you’re a compound heterozygote (like me), that results in a 52% reduction. So, I have slightly less than half the enzymatic activity for MTHFR than a normal, non-mutant.

MTHFR and depression

That all seems pretty straightforward, but take a look at the plethora of studies that exist on the internet, and you’ll see why I was cautious. Some have found significant relationships between MTHFR polymorphisms and psychiatric conditions, and yet others haven’t. There are some studies that say that there is no difference between mutant and control subjects when it comes to depression. Others suggest that carrying a mutated MTHFR allele predicts depression when the person is exposed to childhood trauma.

Most of the studies I’ve seen, including meta-analyses, lean towards accepting a link between MTHFR and depression, especially for homozygotes, who have the least MTHFR activity. Experiments have shown evidence that active folate supplementation can be an effective adjunct therapy for treatment-resistant depression.

The consensus seems to be that more research is needed, although increasingly, there does seem to be a relationship between MTHFR and depression.

For me, I’m content to believe that at least some of my struggles can be traced back to MTHFR. The supplement does seem to make my antidepressants more effective. Plus, that’s not all that my genetic report showed. I also have a weird serotonin transporter that makes SSRIs less effective and increases my cortisol release in response to stress. I’m glad I did the test, at the very least because it helped me to accept my disorder as valid and offered insights into my mental health..

The future of mental health treatment

Is this a sure-fire way to treat mental illness? I’d say not yet, but it’s certainly valuable. Personalized medicine seems to be a buzzword floating around these days, and the implications of genetic research for how we approach mental illness are fascinating. Maybe when the relationships between genes and mental illness are elucidated a little more clearly, we can finally kick the stigma and misconceptions out the door. One can hope, at least.

(Featured image credited to: Abogomazova – Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=25074990)

Letter to Myself About Depression

GenevieveLeave a comment

Dear Future Brain,
It’s been some time since you’ve been where I am, and I wanted to remind you of some lessons I’ve recently learned about depression and self-care.

1. You matter.

I hope that by the time you’re reading this, you sincerely believe this one. I know that we often get lost in existential quicksand. Try to remember that the things you think are indicators of an inconsequential existence can be viewed just as easily as miraculous and precious. Yes, the lifespan of a human being is practically instantaneous in comparison to the existence of the universe. And yes, multi-cellular life may have arisen by accident. But consider this: the fact that you are here, a teeming community of human and bacterial cells piloted by a blob of electrified tissue, is pretty incredible.

2. Listen to your body.

It’s not always easy. In fact, I’m learning that it usually feels like I’m guessing. If this is something you’ve lost touch with, refresh your memory of #1. Natural selection may have screwed you over when it comes to the arrangement of your food pipe and your air pipe (thank you, epiglottis), but it did ok when it came to your nervous system. Yours in particular may be a little out of whack, but it still keeps you alive. Try not to discount your body; it probably knows what it’s doing.

3. You require deliberate (and likely extra) self-care.

Because listening to your body doesn’t come easily, it’s important for you to make an effort to hear it. If that means being a hermit for a few hours every afternoon, so be it. Hopefully you’ve got this one mastered and it feels more natural, but if you still have to work at it, that’s ok. It’s worth it.

4. Depression does not make you a burden.

‘Nuff said.

5. Needing medication is not shameful.

I know, you were mortified when you had to get a bigger pill organizer because you couldn’t fit all your pills for depression in your old one (to be fair, those vitamins are freaking huge). And every time you fill a new prescription, you worry that the pharmacist thinks you’re a nut, but I assure you, she doesn’t.

6. Movement is wonderful.

It’s easy for us to be sedentary for way too long, and since we’re a creature of habit, breaking out of that pattern is tough. Take my word for it though; moving makes you feel better.
P.S. exercise doesn’t have to be difficult.

7. Seek meaningful connection.

Being isolated is tempting, and it’s necessary at times, but it doesn’t serve you in large doses. Whether it’s maintaining your existing relationships or reaching out to someone new, social connection is a vital component of your happiness.

8. Keep growing.

Growth takes lots of forms, and it’s not always about taking a big risk. Stick your toe outside of your comfort zone every once in a while, and believe me when I say that you’re more than capable. If you don’t stretch yourself, your comfort zone will just keep shrinking.

9. Practice gratitude.

This is not to say that your pain is invalid because of the positive parts of your life. Instead, acknowledging the things that you’re thankful for can make the tough stuff a little easier.

10. Have hope.

Depending on where you’re at, this may seem like a meaningless platitude. If that’s the case, I don’t think I can convince you to believe it. Someone once told me that they’d hold the hope for me, so for now, I’ll hold the hope for you. You from the past is rooting for you. You’ve got this.

Love,
Your Brain

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