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Changing My Depression Medication

December 22, 2020November 10, 2021 Genevieve6 Comments

It’s come to my attention that my depression medication doesn’t seem to be doing much. IV ketamine infusions are also doing less than they used to, unless it’s the case they they’re doing just as much but my brain is kicking its level of stubbornness up a few notches. Who’s to say what the cause is? Maybe it’s just the curse of 2020.

I got sidetracked. The point of this post is this: I’m about to start taking Wellbutrin, a medication that I tried a few years ago and really liked. I was only on it for about a week, though, because I promptly broke out in a blotchy rash that spread from my chest, up my neck, and all over my face.

close-up-of-woman's-collarbone-area-with-blotchy-red-rash — (*the rash of 2018)*

It seemed like a cruel joke played on me by the universe. The only oral antidepressant I’d ever tried that made a sudden, discernable difference in my depression is one that I’m allergic to.

Cut to now – I’m once again finding myself floundering in the soupy mashed potatoes of my depressed brain, looking for some way to change things. I’ve always carried a little bit of disappointment about my failed Wellbutrin trial, especially because I was taking the generic at the time. What if I wouldn’t have a reaction to the brand name version? Would it be stupid to try?

You know those prescription medication commercials that include a disclaimer like “Don’t take [name of drug] if you’re allergic to [name of drug],” and you’re like “Well, DUH?” I am now the person that those disclaimers target. To me, the risk of an allergic reaction is worth the potential benefit of taking Wellbutrin. I think it’s telling that when faced with the possibility of a rash, swelling, even anaphylaxis (unlikely), my reaction is “sign me up.”

I remember being so amazed at how motivated Wellbutrin made me feel. It was the only oral depression medication that’s ever given me that “I didn’t fully realize how depressed I was until I wasn’t” feeling. I was in my last semester of college when I took it. By that point, I had tried several medications and was struggling to get through the last few months before graduation. I was over the moon when I realized that Wellbutrin was working for me. It was SO much easier to get my work done and interact with people, even just for the few days that I was on it. When I got the rash, I stopped taking it abruptly, and the sudden changes did not do good things to my mental health. I had already been utterly overwhelmed by classwork and worn down by the near-constant suicidal thoughts that had plagued me for over a year. I canceled my trip home for spring break because I wanted to be alone, and I reluctantly started yet another combo of meds. I just remember the whole thing being bitterly disappointing. It was like Wellbutrin had swooped in, showed me how much easier everything could be, and then ditched me with the gift of an itchy, burning rash after just a few days.

So, I’ll take the chance of a rash if it means I might feel better. That said, if I let myself get too hopeful and the result is a letdown, I know I would feel incredibly defeated. I’m trying to temper my expectations. If I get a rash or if it doesn’t work, at least I’ll finally know for sure if it’s an option for me. I’ll write an update soon.

The Taste of Music: The Ketamine Chronicles (Part 26)

November 21, 2020November 18, 2021 Genevieve5 Comments

The last couple of weeks have been hard for me when it comes to depression. I recently wrote about how IV ketamine can make me feel like I’ve been launched out of a metaphorical cannon. The last time, it was like a little pbthpbpthh – an underwhelming puff that was more like being propelled by air coming out of an untied balloon than like being launched out of a cannon. I don’t remember much at all of the previous ketamine infusion, so I didn’t push myself to write about it. I thought it would likely be boring, anyway.

The Ups and Downs of Ketamine and Depression

I can’t say for sure why that IV ketamine treatment was less effective than others. It could be hormones. It could be the changing seasons. It could be that I haven’t been exercising much. Maybe it’s all three. Whatever the reason(s), I’ve been front seat on the struggle bus – sleeping in my clothes multiple nights in a row and then wearing them the next day, getting my work done late or barely on time, napping by mid-morning. I find myself paring down my daily activities. Prioritizing one thing means getting rid of another thing, as the energy needed to do both is more than I have. In some ways, I’ve been getting along ok – my mood has been dipping here and there. But overall, that hasn’t been terrible. The hardest part is honestly the lack of energy.

Dissociation with IV Ketamine for Depression

So, I’m hoping that this week’s ketamine infusion can knock me back into better functioning. One change this time around is that I decided to stop using scopolamine for my infusions. I used it the last time and it resulted in a very…buried experience. I’m not sure how else to describe it. It was sort of smothering – as though I had sunk far, far below the surface of the Earth, and there was nothing I could do to get back to the room.

Every once in a while, from leagues above me, I’d hear someone tell me to take a deep breath – the pulse oximeter on my finger had alerted them to the fact that I had stopped breathing. And I found that often, I just did not care. I felt like my body was just a suit I was wearing, and maintaining it was proving to be a lot of work. I could feel that my heart rate was slowing and my lungs were waiting for me to inhale, but it didn’t feel like it was innately me, and so I was content to just watch it happen. In fact, when I was told to breathe in, my recollection is that I felt a little annoyed at having to exert the effort. A couple of times, I tried to ignore it, but the voice was persistent, so I relented.

My experience with scopolamine is not entirely strange, I don’t think. Apparently, it can add to the dissociation that ketamine produces, which explains my sense that my body was not really a part of me. My description of that infusion is a little unsettling in hindsight, but in the moment, I don’t remember being afraid or anxious at all. Actually, the whole infusion was very relaxing, minus the slight annoyance of having to breathe. You know, those fragile humans, needing oxygen. Geez.

Acceptance and Flow in Depression Treatment with Ketamine

The most notable aspect of this infusion in my memory is that at some point, my music stopped. I’ve never had an infusion in which there was no music, so when I noticed its absence, I was mildly worried about what it would be like without it. Not worried enough to move or to say something, of course. That would be too much work. So I just waited, accepting that it wasn’t what I had planned for, but that was okay.

Noise in the IV Ketamine Clinic

The sounds of the room, which are often prominent at the beginning of my infusions but fade away as time goes on, were extremely loud. I was most aware of the infusion pump next to me, which emitted constant mechanical noise. My mother was typing in the corner, and every once in a while, I noticed the sounds of papers shuffling or a door closing. I remember thinking that I felt like a pillar in a sandstorm, tiny particles being whipped into motion around me. The sand was the noise, and as it bounced off me and flew around the room, it started to sound a little like music. Rhythmic whirring from the machine combined with staccato typing somehow resulted in organic, landscape-based images in my mind. There were lots of shades of brown, but that’s pretty much all I can remember.

Brief Synesthesia?

Another first for me this time was that I seem to have experienced synesthesia. To some degree, I think I always come close to it during ketamine infusions – the way I associate music with colors and images is not something I’m able to do when lucid. This time, though, I could taste sound. I can’t quite conjure it up enough in my memory to understand what it was like, but I do remember it dawning on me that tasting sounds is not something people usually do.

When the noise in the room morphed into strange music, I became distinctly aware of the inside of my mouth. My tongue felt oddly small in the cavernous space behind my teeth, and the general feeling was of something… earthy. There is absolutely no way I can accurately compare the experience to anything, especially because I don’t remember it clearly enough. As I wrote in my hasty, post-infusion notes, “I can taste music. Indescribable.”

Images from My Subconscious

The rest of the ketamine infusion is jumbled in my memory, but I’m pretty sure the other images I can remember were from the beginning, when the music was still playing. I remember watching dogs eating something, and then their faces stretched and stretched until they turned into alligators. Eventually, an alligator head kept on stretching until it turned into the tendons of a human hand, which stretched until they were the layers of a landscape. Somehow, my brain went from dogs to alligators to tendons to landscape. I could explain the associations from my recent thoughts and experiences, but it would be convoluted. Suffice it to say, all of the elements of that bizarre sequence somehow make sense to me. Brains are fascinating.

Seeing Improvement in Depression Symptoms

Given my general lack of response to the previous IV ketamine treatment, we tried adding magnesium to this most recent one. It’s been two days now since my infusion, and I am definitely feeling a bit better. I woke up this morning, put on clean clothes, washed my face, and did three laps at the dog park instead of one. Improvement is improvement, no matter how small!

If you’d like to read more about my experience with ketamine for depression, start from the beginning of The Ketamine Chronicles or visit the archives. Click here for mobile-optimized archives of The Ketamine Chronicles.

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Working on Depression

October 29, 2020November 24, 2021 Genevieve1 Comment

Sometimes I feel like a bird that can’t figure out how to fly. I periodically get launched out of a cannon (in this metaphor, that’s due to IV ketamine treatment for depression), then flap and flap to no effect. I’m trying to make progress, but gravity is always there. Eventually, I sink lower and lower, just exhausting myself with all that flapping.

That’s how it feels, but I don’t think that’s entirely accurate. Yeah, ketamine wears off eventually, and yeah, my brain has a biochemical problem that means I can’t fix depression just by flapping. But the flapping is doing something. All that work I put into therapy and maintaining a routine and getting exercise must be functioning in tandem with the IV ketamine to push my little bird wings just a smidge farther.

I know this because my mood still dips pretty low sometimes, but on the whole, I’m in a better place than I was a few months ago. Perhaps it’s that I bounce back faster, now. Or maybe it’s just knowing that it won’t last forever.

And now, being able to look back and see that I’m flippity flapping on my own a little makes it just a little bit easier to continue. Chipping away at something day by day is tedious and frustrating, but all of that work adds up. If you can look back at where you were a little while ago, it helps to notice that in working on depression, you have made progress, even if it’s just in the personal growth or a skill you’ve learned or the support you’ve gotten.

Keep flapping, everybody.

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Owl Eye: The Ketamine Chronicles (Part 25)

October 16, 2020May 5, 2022 GenevieveLeave a comment

IV ketamine treatment for depression is one of multiple treatments I use for my mental health. We’re still adjusting it and trying new doses as things change, which makes for interesting little self-experiments. Last time, we went without propofol and discovered that it was fine for me; in fact, I preferred it. This time, I forgot to check for refills on my scopolamine prescription, so I didn’t use any prior to my appointment. With no propofol, no scopolamine, and a slightly higher dose, this ketamine infusion felt remarkably vivid. It was much like the first few ketamine infusions I had, which were dominated by immersive scenes and imagery that constantly changed.

IV Ketamine Treatment for Depression Feels New Every Time

I felt it quickly this time, the room beginning to sway and bend even before I fully settled in and closed my eyes. Still, I only saw darkness for what felt like a long time but was probably only a minute or two. Then, subtle lines took shape, and my mental lens zoomed in on an owl’s face. The eye was my focus – although the steely beak caught my attention as well. The image rotated slowly before fading away, the owl’s eye staring back at me.

After the rotating owl, the sounds of the room made an appearance in my mind. The gentle chug chugging of the infusion pump reminded me of a train, and I soon saw one on the horizon of my internal view. It belched smoke – an early, coal-powered one – and rumbled closer and closer. The black smoke filled the air, blocking my vision until all that remained was a small view of the front of the train as it trundled by. Black smoke, liquid, or goop filling my vision was something of a theme in this ketamine infusion. On other occasions, it expanded from small blobs until they met and pressed against one another, filling whatever volume my mental space contained while I tried to see through a narrowing hole.

Memory Recall During Ketamine Therapy

If I’m correctly piecing this together from my garbled and typo-riddled notes, which I took in the car on my way home, the sensation of being smothered by the black smoke brought my awareness to my mask. This, in turn, created an image of cloth above my face, with an illegible tag sewn into the seam (a common theme in my infusions is not being able to decipher letters or numbers).

My mind then conjured up a lovely memory of building a couch fort with my brother as kids. The memory itself was jumbled and consisted of snapshots – balancing the cushions just right, sliding head-first over the arm of the couch and down into the fort, and sitting with my knees pulled up in the dark confines of our shared space. The most convincing parts of the memory were the sensations. I could feel the texture of the couch upholstery and the give of the stuffing in the cushions. I noted the darkness with cracks of light where the cushions didn’t meet, and the feeling of the seat cushion grazing the top of my head. I don’t think I’ve ever re-experienced a memory during a ketamine infusion before. It was a comforting feeling to be returned to the experience of being a kid, entranced in the moment by the fantasy of a simple couch fort.

Recurring Themes in Depression Treatment

As usual, water made an appearance in my ketamine dreams. This time, it began with a slowly spinning whirlpool of green/yellow water, lit from within to make the water glow. Soon, I was in the whirlpool, and it turned into the ocean. The water swelled around me, and wave after wave overtook me until I was underwater. It was not frightening, although in describing it, I realize it sounds a lot like I was drowning. Once underwater, I saw an apparently incredible scene which I do not remember but my notes describe as, “Turtle? Fish on lines like balloons. Underwater city of fantastical things.”

A purple striped fish with spiky fins in the ocean. — *Photo by Sophia Muller on Unsplash*

If only I could remember. What treasures have been lost in the depths of my brain? (Water puns fully intended.)

Altered Visual Perception and Ketamine

I returned to the room several times during this infusion, convinced that it must be over soon, only to find that the people had swapped or left or reappeared. My mother had gone to run an errand and had dropped me off but returned partway through my infusion. I saw her sitting in the corner maybe four feet from me, yet it seemed that she was very, very far away. It was a little like looking through the wrong end of binoculars. I tried to read her expression – was she even looking at me? The more I tried to settle my gaze on her, the more my eyes refused to cooperate. They jumped around and made double images, and eventually, I admitted defeat and closed them once again.

Sense of Time During Ketamine Infusions

The scenes and images I was seeing were so numerous that they seemed to be packed into time in an unbelievable manner. It’s strange to think that I could experience so much in such a short amount of time, but even after all of that, there was more. I remember walking over a mountain range with an enormously tall man – I was also enormous – while he proudly described in great detail how he made the mountains. In another scene, a golden dog (I think it was a statue?) was hidden in a room packed with items. My notes reference my teeth feeling soft, something about lizard scales, and robotic cats. “What if they found my head underneath San Francisco?” must have been in response to an extremely bizarre episode of Star Trek that I recently watched in which Data’s head is found during an archaeological dig underneath – you guessed it – San Francisco.

I’m so glad that I took notes on my phone immediately after my ketamine appointment, because I find that the memory of it fades over time unless I can remind myself of what I saw. I was functioning pretty well after my IV ketamine treatment and was able to get myself to take notes rather than close my eyes on the way home. The rest of the day was fairly pleasant. I greatly prefer infusions without propofol both because of its effects during the infusion as well as because of how it alters the rest of the day. Of course, I wasn’t entirely myself until several hours afterward. I took my shoes off somewhere in the house upon getting home and promptly lost them. I could not figure out where I put them until I found them the next day in a closet. Why would I put them away?! In a closet?? Absurd.

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A Ghost Town: The Ketamine Chronicles (Part 22)

August 6, 2020May 5, 2022 Genevieve3 Comments

I woke up a couple of hours after going to bed following my most recent IV ketamine treatment for depression. It was around 1 o’clock when I began my slumber, so when Stella woke me up, looking like she needed something, I automatically fed her dinner because it felt like I had been asleep for a long time. Then I wandered into the living room, where it dawned on me that bright sunlight was streaming in through the windows.

What day is it? Is it still daytime?

Temporary Disorientation After IV Ketamine Treatment for Depression

Perhaps I entered a different dimension where time passes more slowly. Or maybe I’m taller than the moon and my head is therefore circling the sun at a different rate. I went back to sleep, but apparently woke up periodically to accomplish my nightly routine. Wednesday’s cubby in my pill organizer is empty, and I vaguely remember flossing my teeth. Half of what I wrote here was already done, which surprised me when I opened my laptop this morning to write. My phone informs me that today is Thursday, although it feels like several days have passed since yesterday’s ketamine infusion treatment.

An IV Ketamine Therapy Reset

I usually go about three weeks between appointments, but my depression has made a comeback. Similar to how I first began getting ketamine infusions, we decided to do a short series of infusions in quick succession to try to reset things and boost my mood. In addition to the short series, we’re also trying another medicine that can enhance the effects of ketamine therapy.

Scopolamine is an anti-nausea drug that comes in the form of a patch that you place behind your ear. I can tell that it did something; the infusion itself felt more enveloping than usual, and for hours afterward, I had this weird sense that I could feel my blood traveling through my blood vessels. It almost felt like being squeezed – like the boundaries of my body were working harder to keep everything contained within my skin.

I talked to Dr. Grindle (whose name frequently autocorrects to Dr. Griddle, which I think is hilarious) about our plan of action at the beginning of the appointment. My previous infusion was my first experience with ketamine-assisted psychotherapy (KAP). The goal of it was to help me bypass the frustrating barriers to talking that I run into in therapy by having a ketamine infusion and a therapy session at the same time. It was a fascinating experience, but also a little overwhelming, so I decided to just do a normal ketamine infusion yesterday. I’ll revisit KAP another time.

Building a Metaphorical Mental Health Bridge

I don’t remember much from this infusion. The addition of all these other anti-nausea and sedating medications makes it hard to remember what I thought about and saw during the infusion. They also make me crash when I get home, which lets whatever memories I do have fade away before I have a chance to write them down. One part that I can vaguely recall came from a suggestion made by my therapist. After our KAP session last week, we marveled at how much I resisted talking about particular topics, even while zonked out on ketamine. This week, she suggested that I imagine building a bridge across the moat that protects my mental fortress. I have yet to figure out why some parts of my everyday life show up in my IV ketamine treatments and some don’t. The image of a bridge over a moat certainly stuck, although probably not in the way that my therapist hoped it would.

Mixing Memory and Imagination

Thinking about castles and fortresses created an odd merging of memories and imagination in my mind. At first, I found myself thinking about the ruins of castles on the Danube River in Germany and in the rolling hills in Wales. I imagined the people who lived in those castles milling about and going about their daily lives. Then, I seemed to combine that train of thought with memories I have of going to Caribou, an old silver-mining ghost town from the 1870s. It’s situated not far from where I grew up.

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Caribou-Colorado-ghost-town-during-summer-of-early-21st-century

We used to go up there and explore the crumbling stone structures and look for currants and wild raspberry bushes. In my distorted ketamine haze, I saw people working in the half-built structures. All of the trappings of normal life were there; a large pot in the fireplace, a sturdy wooden table on the dirt floor, women in long, pioneer dresses and aprons bustling around in the four walls under the open sky.

Mental Barriers

At some point, the ruins were surrounded by a moat, and a figure stood on the opposite side. Remembering that I was trying to let the person cross the moat, I conjured up a drawbridge. Interestingly, simply creating the bridge was not enough. I couldn’t seem to keep the drawbridge down; it kept raising over the water, leaving the moat impassable again. It was somewhat frustrating – like those dreams where everything keeps going wrong, no matter how much you try to find a way around it. I suppose next time, I should build any bridge but a drawbridge.

A Middle Ground with Major Depression

I feel a little bit better. When I’m awake, I feel more motivated to get things done, and my immediate reaction to being faced with an opportunity or an obligation is not automatically, “Ugh. No.” This is one of the more frustrating phases of depression for me. I feel capable of doing things, I sometimes even want to do things, but I’m so unbelievably tired that I waste hour after hour asleep. I’m starting to wonder if that’s a normal depression symptom plus side effects of the medicines I take, or something else entirely. All I know is that it makes me feel enormously lazy when I wake up at 5:30am and am struggling to keep my eyes open only three hours later. It hasn’t always been that way; when I was first diagnosed with major depressive disorder, I didn’t feel the need to take a nap until mid-afternoon, and I could limit it to something more reasonable. I’m not sure what happened besides a worsening of my illness and the meds I take, or if those factors explain it all. Something to ponder.

A stretch of straight open road with a body of water to the left and blue sky above

The Day 2 Mystery of Depression Treatment: The Ketamine Chronicles (Part 17)

May 10, 2020November 20, 2021 GenevieveLeave a comment

It’s been two days since my most recent ketamine infusion, which I have administered by my doctor to treat my depression. Usually, I write these posts in The Ketamine Chronicles as soon as I’m able so as to not forget too much of the bizarre experience. This time, I found that I didn’t have much to say immediately following my ketamine infusion.

Ketamine for Depression Has Not Been a Straight Line

For transparency’s sake in my attempt to document my experience with ketamine treatment for depression, I’ll just say it. My mental health has been in decline over the last few weeks, to the point of struggling once again with self-harm, something I thought I had kicked over a year ago. The previous ketamine infusion seemed not to do much for me in terms of mood, but gave me more energy and motivation, a mismatch that left me restless and confused. I felt the drive to do something but had no desire to follow through. Perhaps this is what led me back to self-harm. Multiple stressors, not exercising as frequently, and a strange mix of motivation and hopelessness led me back to an old, unhealthy coping mechanism.

A dense forest with thick fog and a path extending down the middle. — *Photo by Andrew Neel on Unsplash*

No Memory of Higher Ketamine Doses

I had my most recent ketamine infusion on Friday. Like last time, it was relatively empty of bizarre images, at least that I can remember. At this point, my dose is pretty much at the upper limit of ketamine for my body, so Dr. G has been giving me propofol to make the experience less trippy. In my last ketamine infusion, I stubbornly kept my eyes open for a lot of the infusion and seemed not to care about breathing. This time, I don’t think I could have opened my eyes if I’d tried. I remember chatting with Erin, the PA, while she got the I.V. set up. I know we talked about haircuts, but I’m not sure what else. The propofol hit me way before the ketamine did, and the last thing I remember is Dr. G taking an exaggerated deep breath and wagging his finger at me sternly before leaving me in Erin’s capable hands.

Breaking the Speed Limit

When I closed my eyes, the world disappeared above me as I sank down into peaceful nothingness. At some point, I remember feeling as though I were a passenger in a car on a highway, open road stretching ahead of me. We began to go a little too fast for my liking, but I was stuck– carried along by the seat beneath me. This is the only image I remember with clarity from this infusion. I also remember that, because I couldn’t feel my face, I was occasionally concerned that I may have taken my mask off. Laughable in hindsight that I thought I could have moved with enough coordination to do that.

Ketamine on the Second Day

Yesterday, the day after my ketamine infusion, I felt no different than I have for the past few weeks. Actually, I think I may have felt worse. But today, I awoke with a wonderful sense of relief from my symptoms. Whether this lasts remains to be seen, but it follows an interesting pattern. The day immediately following an infusion is often disappointing for me. I’ve learned to not put too much stock into whether or not a ketamine infusion has helped based on the day after. The second day, however, is usually when I notice the changes that ketamine creates. I don’t know how common this is, but I think it’s interesting.

I have already put on my exercise clothes, anticipating a long run later in the day. I’m looking forward to today’s project of re-painting the grape arbors. I have mental plans to clean the kitchen and change my sheets, and maybe even vacuum. It’s great to feel better, but the previous few weeks have me apprehensive about this infusion; will it last? Will I need to adjust my medication or have more ketamine infusions to stabilize my depression?

We shall see. But for now, it’s nice to feel a bit better.

Close Your Eyes: The Ketamine Chronicles (Part 16)

April 19, 2020May 5, 2022 Genevieve3 Comments

“I think Stella is a bad influence,” is a phrase I remember hearing Dr. G say during my latest ketamine infusion for depression. Stella is my willful, independent dog who sometimes flat-out refuses to listen to me. In trying to piece together the events of my day, that phrase bounced around in my head without context. What had happened?

Apparently, I had refused to close my eyes. Dr. G repeatedly told me to shut them, but dang it if that little glass dragonfly suspended from the ceiling wasn’t absolutely mesmerizing. I remember it glittering and moving gently while I stared. I closed my eyes eventually.

Some Changes to My Ketamine Infusion

This infusion was different from what I described in previous posts of The Ketamine Chronicles in a few ways. For one thing, it was a higher dose of ketamine paired with a sedative to make it less intense. I also am completely off of one of my mood-stabilizing medications, Lamictal, which can interfere with ketamine. Like my previous ketamine infusion, I took some Tagamet before my infusion to slow the metabolism of the ketamine and make it last longer. The sedative kept this infusion from being bizarre, or at least from me remembering any bizarre images I might have seen.

Abstract architecture made of long, connected panels like scales. — *Photo by Luca Bravo on Unsplash.*

Dissociation with Ketamine Treatments

At first, I didn’t feel as deeply removed from the world around me as usual. This was deceptive, though, as I soon began to feel – as trippy as this sounds – like my being was shrinking into my body. Or perhaps like my body was expanding to create a shell around my consciousness. Things were happening in the room – sounds of typing and clicking, machines beeping, Dr. G telling me to take a deep breath (which I also did not listen to, apparently) – but they all seemed so far away as to be completely beyond my caring.

I opened my eyes periodically to see what was going on and, due to the dissociative effects of ketamine, usually got sucked into the computer monitor, which displayed a series of calming images of winter mountains. This is the danger of not wearing a sleep mask; when you’re hooked up to a ketamine infusion, EVERYTHING looks interesting and it’s incredibly tempting to let all of your automatic functions, like blinking and breathing, be abandoned in favor of absorbing whatever magical thing you’re looking at. Nothing matters more than watching a snowy peak meld into a pine forest. Nothing.

Monitoring Vitals During Ketamine Infusions

It’s a strange experience to realize that you haven’t breathed in a while but not find that alarming at all. In fact, the longer I went without breathing, the harder it seemed to do. It’s sort of a heavy slowness that keeps me from breathing deeply. It has to be quite deliberate. My vital signs are monitored during ketamine infusions, so if my blood oxygenation drops or some other concerning development occurs, my doctor is alerted right away. I’ve had to be reminded to breathe during previous infusions, but a simple, “Hey, take a deep breath,” always seems to break through my trance easily. This time, Dr. G repeatedly telling me to take a deep breath reminded me that breathing was a thing that people did, but I found myself reluctant to put in the effort. There wasn’t much that I cared about doing, and I remember thinking that I felt oddly cushioned against the ketamine.

Intersecting scrabble tiles spelling inhale, exhale, and repeat. — *Photo by Brett Jordan on Unsplash*

Sleeping off a Ketamine Infusion

Afterward, I tottered down the steps to the car and marveled at my mom’s apparent lightning reflexes as she drove us home. We stopped at the pharmacy and grocery store (a whole day of essential outings!) and I simply put my seat back and waited in the car while my mom went in. Unable to get comfortable, I flopped around until the car got too warm. I cracked the door open and leaned out a little to get some fresh air, resting my head against the door frame. I wonder what people in the parking lot thought. I was clearly not very with it and kept doing that embarrassing head-jerk that happens when you fall asleep sitting up.

When we got home, I crashed for several hours, then got up and walked the dog around the block. I didn’t think much about how I was acting until I passed a house and then noticed someone sitting on their porch. I had been walking a few steps, stopping for Stella to smell something, zoning out, then repeating all the way around the neighborhood. I have no idea how long I stood in front of that person’s porch with a blank look on my face, but it might have been much too long to look normal. Who knows – maybe they thought it was quarantine brain.

Love, Your Brain

Tag: Major Depressive Disorder